What is holocrine secretion?

Holocrine secretion is characterized by the process in which secretory cells accumulate various substances and ultimately become engorged or distended with these products. When the cells reach a certain threshold of fullness, they rupture, releasing their entire contents into the duct or cavity. This method of secretion is distinctly different from other secretion methods, such as merocrine, where cells release substances via exocytosis without damaging the cell.

This context explains the mechanism of holocrine secretion and highlights its unique aspect; unlike other types that preserve cell integrity, holocrine secretion entails the complete destruction of the secretory cell to deliver its contents. Therefore, it is particularly observed in certain glands, such as sebaceous glands associated with hair follicles, where the strategy is to release sebum (oil) effectively by this method.