Which cells initiate the inflammatory response when stimulated?

Mast cells are key players in the initiation of the inflammatory response. They contain granules that are filled with histamine and other mediators, which are released when the cells are activated by injury or allergens. This release leads to vasodilation and increased permeability of blood vessels, allowing immune cells to access the affected area more easily. As a result, they play a critical role in the early stages of inflammation, acting as sentinels of the immune system that detect foreign pathogens and trigger the inflammatory process.

Mast cells can also interact with other immune cells, enhancing the overall inflammatory response. Their strategic location near blood vessels and surfaces (like the skin and mucosal barriers) ensures a rapid response to various stimuli, emphasizing their role as initiators of inflammation.